Paracrine signaling between carcinoma cells and mesenchymal stem cells generates cancer stem cell niche via epithelial-mesenchymal transition.
نویسندگان
چکیده
Li and colleagues present data that cancer cell-derived interleukin-1 induces prostaglandin E(2) and cytokine secretion in mesenchymal stem cells (MSC) to activate β-catenin signaling in the cancer cell. This paracrine signaling between carcinoma cells and MSC leads to the creation of a cancer stem cell niche via epithelial-mesenchymal transition.
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ورودعنوان ژورنال:
- Cancer discovery
دوره 2 9 شماره
صفحات -
تاریخ انتشار 2012